The gut microbiome regulates memory function

Journal article

E. Noble, C. A. Olson, E. Davis, Linda Tsan, Yen-Wei Chen, Ruth Schade, Clarissa M. Liu, A. Suarez, Roshonda B Jones, M. Goran, C. B. de La Serre, Xia Yang, E. Hsiao, S. Kanoski
bioRxiv, 2020

Semantic Scholar DOI

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APA Click to copy
Noble, E., Olson, C. A., Davis, E., Tsan, L., Chen, Y.-W., Schade, R., … Kanoski, S. (2020). The gut microbiome regulates memory function. BioRxiv.

Chicago/Turabian Click to copy
Noble, E., C. A. Olson, E. Davis, Linda Tsan, Yen-Wei Chen, Ruth Schade, Clarissa M. Liu, et al. “The Gut Microbiome Regulates Memory Function.” bioRxiv (2020).

MLA Click to copy
Noble, E., et al. “The Gut Microbiome Regulates Memory Function.” BioRxiv, 2020.

BibTeX Click to copy

@article{e2020a,
  title = {The gut microbiome regulates memory function},
  year = {2020},
  journal = {bioRxiv},
  author = {Noble, E. and Olson, C. A. and Davis, E. and Tsan, Linda and Chen, Yen-Wei and Schade, Ruth and Liu, Clarissa M. and Suarez, A. and Jones, Roshonda B and Goran, M. and de La Serre, C. B. and Yang, Xia and Hsiao, E. and Kanoski, S.}
}

Abstract

Emerging evidence highlights a critical relationship between gut microbiota and neurocognitive development. Here we explore whether excessive early life consumption of added sugars negatively impacts neurocognitive development via the gut microbiome. Using a rodent model of sugar-sweetened beverage (SSB) consumption during adolescence, we show that excessive early life sugar intake impairs adult hippocampal-dependent memory function while preserving other neurocognitive domains. Adolescent SSB consumption during adolescence also elevates fecal microbial abundance of Parabacteroides, which negatively correlates with memory task performance. Transferred enrichment of Parabacteroides species P. distasonis and P. johnsonii in adolescent rats impairs memory function during adulthood. Hippocampus transcriptome analyses identify gene expression alterations in neurotransmitter synaptic signaling, intracellular kinase signaling, metabolic function, neurodegenerative disease, and dopaminergic synaptic signaling-associated pathways as potential mechanisms linking bacterial alterations with memory impairment. Collectively these results identify a role for microbiota “dysbiosis” in mediating the negative effects of early life unhealthy dietary factors on neurocognitive outcomes.